| 1 | 4 Nov 2022 | TBA | 1 Mountain Ridge vs BYE | |
| 2 | 4 Nov 2022 | 19:00 | 4 Northern Garrett 36 - 0 5 Smithsburg | |
| 3 | 5 Nov 2022 | 15:30 | 3 Allegany 43 - 7 6 Clear Spring | |
| 4 | 4 Nov 2022 | 19:00 | 2 Fort Hill 74 - 0 7 Southern Garrett | |
| 5 | 4 Nov 2022 | 18:00 | 1 Joppatowne 44 - 2 8 Havre de Grace | |
| 6 | 3 Nov 2022 | TBA | 4 Loch Raven 26 - 32 5 SEED School | |
| 7 | 4 Nov 2022 | 19:00 | 3 Brunswick 21 - 14 6 Catoctin | |
| 8 | 4 Nov 2022 | 19:00 | 2 Patterson Mill 28 - 0 7 Pikesville | |
| 9 | 4 Nov 2022 | TBA | 1 Forest Park vs BYE | |
| 10 | 4 Nov 2022 | 18:00 | 4 Edmondson-Westside 34 - 8 5 Reginald F Lewis | |
| 11 | 4 Nov 2022 | 15:00 | 3 Frederick Douglass-BC 44 - 6 6 Benjamin Franklin | |
| 12 | 4 Nov 2022 | TBA | 2 Lake Clifton vs BYE | |
| 13 | 4 Nov 2022 | 18:00 | 1 Colonel Richardson 1 - 0 8 Washington | |
| 14 | 4 Nov 2022 | 19:00 | 4 Bohemia Manor 57 - 21 5 Surrattsville | |
| 15 | 4 Nov 2022 | 19:00 | 3 Perryville 44 - 14 6 Kent County | |
| 16 | 5 Nov 2022 | 13:00 | 2 Green Street 68 - 6 7 Snow Hill | |
| 17 | 11 Nov 2022 | 19:00 | 1 Mountain Ridge 42 - 6 4 Northern Garrett | |
| 18 | 12 Nov 2022 | 18:00 | 3 Allegany 0 - 48 2 Fort Hill | |
| 19 | 11 Nov 2022 | 19:00 | 1 Joppatowne 72 - 12 5 SEED School | |
| 20 | 11 Nov 2022 | 19:00 | 3 Brunswick 21 - 14 2 Patterson Mill | |
| 21 | 12 Nov 2022 | 12:00 | 1 Forest Park 46 - 14 4 Edmondson-Westside | |
| 22 | 12 Nov 2022 | 12:00 | 3 Frederick Douglass-BC 20 - 28 2 Lake Clifton | |
| 23 | 11 Nov 2022 | 18:00 | 1 Colonel Richardson 13 - 14 4 Bohemia Manor | |
| 24 | 12 Nov 2022 | 12:00 | 3 Perryville 17 - 16 2 Green Street | |
| 25 | 18 Nov 2022 | 18:30 | 1 Mountain Ridge 57 - 0 8 Bohemia Manor | |
| 26 | 18 Nov 2022 | 19:00 | 4 Brunswick 17 - 8 5 Forest Park | |
| 27 | 18 Nov 2022 | 18:30 | 3 Joppatowne 38 - 30 6 Lake Clifton | |
| 28 | 18 Nov 2022 | 19:00 | 2 Fort Hill 49 - 7 7 Perryville | |
| 29 | 25 Nov 2022 | 18:30 | 1 Mountain Ridge 49 - 20 4 Brunswick | |
| 30 | 25 Nov 2022 | 18:30 | 3 Joppatowne 6 - 43 2 Fort Hill | |
| 31 | 3 Dec 2022 | 15:30 | 1 Mountain Ridge 14 - 16 2 Fort Hill | |