| 1 | 4 Nov 2022 | TBA | 1 South Carroll vs BYE | |
| 2 | 4 Nov 2022 | 19:00 | 4 Boonsboro 42 - 6 5 Western Tech | |
| 3 | 4 Nov 2022 | 18:00 | 3 Williamsport 41 - 21 6 Winters Mill | |
| 4 | 4 Nov 2022 | 18:30 | 2 Liberty 49 - 6 7 Francis Scott Key | |
| 5 | 4 Nov 2022 | TBA | 1 Dunbar vs BYE | |
| 6 | 4 Nov 2022 | 18:00 | 4 Carver Vo-Tech 14 - 22 5 Fairmont Heights | |
| 7 | 3 Nov 2022 | 18:00 | 3 Sparrows Point 26 - 8 6 Chesapeake-BC | |
| 8 | 4 Nov 2022 | 18:30 | 2 Largo 1 - 0 7 Central | |
| 9 | 4 Nov 2022 | 19:00 | 1 Patuxent 48 - 10 8 Southern | |
| 10 | 4 Nov 2022 | 18:30 | 4 Gwynn Park 20 - 21 5 McDonough | |
| 11 | 4 Nov 2022 | 19:00 | 3 Lackey 43 - 0 6 Friendly | |
| 12 | 4 Nov 2022 | 19:00 | 2 Calvert 50 - 0 7 Crossland | |
| 13 | 4 Nov 2022 | TBA | 1 Rising Sun vs BYE | |
| 14 | 4 Nov 2022 | 19:00 | 4 Elkton 7 - 6 5 Cambridge-South Dorchester | |
| 15 | 4 Nov 2022 | 18:00 | 3 Fallston 24 - 27 6 Parkside | |
| 16 | 4 Nov 2022 | 18:30 | 2 Harford Tech 36 - 0 7 North East | |
| 17 | 11 Nov 2022 | 19:00 | 1 South Carroll 20 - 14 4 Boonsboro | |
| 18 | 12 Nov 2022 | 18:00 | 3 Williamsport 45 - 43 2 Liberty | |
| 19 | 12 Nov 2022 | 16:00 | 1 Dunbar 58 - 0 5 Fairmont Heights | |
| 20 | 12 Nov 2022 | 13:00 | 3 Sparrows Point 14 - 42 2 Largo | |
| 21 | 11 Nov 2022 | 19:00 | 1 Patuxent 37 - 7 5 McDonough | |
| 22 | 11 Nov 2022 | 19:00 | 3 Lackey 13 - 42 2 Calvert | |
| 23 | 11 Nov 2022 | 18:00 | 1 Rising Sun vs 4 Elkton | |
| 24 | 11 Nov 2022 | 18:30 | 6 Parkside 13 - 30 2 Harford Tech | |
| 25 | 18 Nov 2022 | 18:00 | 1 Dunbar 64 - 0 8 Elkton | |
| 26 | 18 Nov 2022 | 19:00 | 4 Calvert 47 - 6 5 Largo | |
| 27 | 18 Nov 2022 | 19:00 | 3 Patuxent 33 - 24 6 Williamsport | |
| 28 | 18 Nov 2022 | 19:00 | 2 South Carroll 7 - 14 7 Harford Tech | |
| 29 | 26 Nov 2022 | 13:00 | 1 Dunbar 46 - 7 4 Calvert | |
| 30 | 25 Nov 2022 | 19:00 | 3 Patuxent 43 - 21 7 Harford Tech | |
| 31 | 3 Dec 2022 | 12:00 | 1 Dunbar 22 - 13 3 Patuxent | |