| 1 | 4 Nov 2022 | TBA | 1 Damascus vs BYE | |
| 2 | 4 Nov 2022 | 18:30 | 4 Rockville 8 - 42 5 Linganore | |
| 3 | 3 Nov 2022 | 18:30 | 3 Oakdale 53 - 0 6 North Hagerstown | |
| 4 | 3 Nov 2022 | 18:30 | 2 Frederick 41 - 0 7 South Hagerstown | |
| 5 | 4 Nov 2022 | 19:00 | 1 Bel Air 48 - 0 8 Towson | |
| 6 | 4 Nov 2022 | 18:00 | 4 Franklin 28 - 25 5 Manchester Valley | |
| 7 | 3 Nov 2022 | 17:30 | 3 Edgewood 49 - 0 6 Patapsco | |
| 8 | 4 Nov 2022 | 19:00 | 2 Westminster 50 - 0 7 Aberdeen | |
| 9 | 4 Nov 2022 | TBA | 1 Atholton vs BYE | |
| 10 | 3 Nov 2022 | 18:00 | 4 Marriotts Ridge 22 - 12 5 Digital Harbor | |
| 11 | 4 Nov 2022 | 19:00 | 3 Wilde Lake 33 - 13 6 Centennial | |
| 12 | 4 Nov 2022 | TBA | 2 River Hill vs BYE | |
| 13 | 4 Nov 2022 | TBA | 1 Northern vs BYE | |
| 14 | 4 Nov 2022 | 19:00 | 4 St. Charles 53 - 16 5 Oxon Hill | |
| 15 | 4 Nov 2022 | 19:00 | 3 Long Reach 22 - 8 6 Crofton | |
| 16 | 4 Nov 2022 | 18:30 | 2 Chesapeake-AA 42 - 6 7 James M Bennett | |
| 17 | 11 Nov 2022 | 16:30 | 1 Damascus 28 - 7 5 Linganore | |
| 18 | 12 Nov 2022 | 14:30 | 3 Oakdale 20 - 17 2 Frederick | |
| 19 | 11 Nov 2022 | 19:00 | 1 Bel Air 7 - 17 4 Franklin | |
| 20 | 11 Nov 2022 | 19:00 | 3 Edgewood 20 - 28 2 Westminster | |
| 21 | 11 Nov 2022 | 19:00 | 1 Atholton 28 - 7 4 Marriotts Ridge | |
| 22 | 11 Nov 2022 | 18:30 | 3 Wilde Lake 0 - 35 2 River Hill | |
| 23 | 11 Nov 2022 | 18:00 | 1 Northern 15 - 22 4 St. Charles | |
| 24 | 11 Nov 2022 | 18:00 | 3 Long Reach 14 - 13 2 Chesapeake-AA | |
| 25 | 18 Nov 2022 | 18:30 | 1 Atholton 6 - 22 8 St. Charles | |
| 26 | 18 Nov 2022 | 19:00 | 4 Westminster 14 - 33 5 Oakdale | |
| 27 | 18 Nov 2022 | 18:30 | 3 Damascus 47 - 12 6 Long Reach | |
| 28 | 18 Nov 2022 | 18:30 | 2 River Hill 7 - 0 7 Franklin | |
| 29 | 25 Nov 2022 | 18:30 | 8 St. Charles 22 - 27 5 Oakdale | |
| 30 | 25 Nov 2022 | 18:30 | 3 Damascus 42 - 7 2 River Hill | |
| 31 | 3 Dec 2022 | 19:00 | 5 Oakdale 14 - 21 3 Damascus | |