| 1 | 4 Nov 2022 | 18:30 | 1 Quince Orchard 56 - 0 8 Clarksburg | |
| 2 | 4 Nov 2022 | 18:30 | 4 Northwest 53 - 6 5 B-CC | |
| 3 | 4 Nov 2022 | 18:30 | 3 Churchill 34 - 21 6 Richard Montgomery | |
| 4 | 4 Nov 2022 | 18:30 | 2 Walter Johnson 28 - 44 7 Gaithersburg | |
| 5 | 4 Nov 2022 | TBA | 1 Blair vs BYE | |
| 6 | 4 Nov 2022 | 18:30 | 4 Einstein 54 - 24 5 Bladensburg | |
| 7 | 5 Nov 2022 | 13:00 | 3 Laurel 24 - 6 6 High Point | |
| 8 | 4 Nov 2022 | 18:30 | 2 Paint Branch 52 - 0 7 Wheaton | |
| 9 | 4 Nov 2022 | 18:30 | 1 Flowers 82 - 0 8 Northwestern | |
| 10 | 5 Nov 2022 | 13:00 | 4 Eleanor Roosevelt 15 - 6 5 Bowie | |
| 11 | 5 Nov 2022 | 13:00 | 3 DuVal 16 - 12 6 Suitland | |
| 12 | 4 Nov 2022 | 19:00 | 2 Wise 49 - 0 7 Parkdale | |
| 13 | 4 Nov 2022 | TBA | 1 Broadneck vs BYE | |
| 14 | 4 Nov 2022 | 17:00 | 4 Meade 27 - 24 5 North County | |
| 15 | 4 Nov 2022 | 18:30 | 3 Glen Burnie 39 - 7 6 Parkville | |
| 16 | 4 Nov 2022 | 18:00 | 2 Old Mill 57 - 22 7 Annapolis | |
| 17 | 12 Nov 2022 | 17:00 | 1 Quince Orchard 24 - 14 4 Northwest | |
| 18 | 11 Nov 2022 | 18:30 | 3 Churchill 27 - 14 7 Gaithersburg | |
| 19 | 11 Nov 2022 | 18:30 | 1 Blair 28 - 0 4 Einstein | |
| 20 | 11 Nov 2022 | 18:30 | 3 Laurel 16 - 42 2 Paint Branch | |
| 21 | 12 Nov 2022 | 13:00 | 1 Flowers 40 - 20 4 Eleanor Roosevelt | |
| 22 | 11 Nov 2022 | 19:00 | 3 DuVal 0 - 49 2 Wise | |
| 23 | 11 Nov 2022 | 18:30 | 1 Broadneck 30 - 13 4 Meade | |
| 24 | 11 Nov 2022 | 18:00 | 3 Glen Burnie 0 - 32 2 Old Mill | |
| 25 | 18 Nov 2022 | 18:30 | 1 Flowers 28 - 6 8 Paint Branch | |
| 26 | 18 Nov 2022 | 18:30 | 4 Blair 7 - 51 5 Wise | |
| 27 | 18 Nov 2022 | 18:30 | 3 Broadneck 39 - 7 6 Churchill | |
| 28 | 18 Nov 2022 | 19:00 | 2 Quince Orchard 21 - 6 7 Old Mill | |
| 29 | 26 Nov 2022 | 13:00 | 1 Flowers 20 - 13 5 Wise | |
| 30 | 25 Nov 2022 | 18:30 | 3 Broadneck 9 - 42 2 Quince Orchard | |
| 31 | 1 Dec 2022 | 19:00 | 1 Flowers 7 - 32 2 Quince Orchard | |